Brayford Studio provides private pregnancy scans and 4D Baby Scans in Lincolnshire

Please note this scan is now available.

Panorama Prenatal Test

The Brayford Studio Lincolnshire,Lincoln, LN6 3QN.
Appointments every day.
Access to Senior Staff opinion.
Ultrasound scan included.
9-12 days for result.
Why choose The Brayford Studio Lincolnshire for your Panorama Test?

Only Clinic providing it in UK outside London
30 - 45 minutes per appointment.
Evening and Sunday appointments available
Sex chromosomes available
Screening for Micro-deletion is now available
Detailed ultrasound scan included
Every case discussed with a senior medical staff when necessary
The only non-invasive prenatal test (NIPT) that can identify TRIPLOIDY.

Package	Price
Panorama Test	From £500.99
Blood test only	From £399.99
Blood test + Scan	From £499.99
Extended Panorama Blood test:	From £650.99
Microdeletions	£150

Call 01522 683 347 to book your Panorama Test

Appointments last 45 minutes including a detailed ultrasound scan.
There is an additional charge for Sunday appointments.
You do not need a referral for any services performed by the Brayford Studio Lincolnshire.
Using our services will not affect your right to NHS care.
The reports and scans we perform are often more comprehensive than NHS equivalent and will be accepted by NHS midwives and consultants. On the rare occasion that it is necessary, and only with your permission, we are also able to discuss your case with your primary provider.

The Panorama Prenatal Test

Blood sample taken from the mother at any time from 9 weeks of pregnancy can be analysed for cell free fetal DNA, which is a marker of the DNA of the baby in the maternal blood. The result of the simple blood test (Panorama) is predictive to more than 99% in Down’s syndrome T21, Edwards syndrome T18 and Patau’s syndrome T13, which will greatly reduce the need for the invasive testing of CVS or amniocentesis. It can also be used to detect other chromosomal abnormalities such as Turners syndrome, monosomy OX, Klinefelter syndrome (XXY), Jacob syndrome (XYY) and Triple X(XXX) or vanishing twin. Panorama test also screen for Triploidy, can sex the baby if required and pick up micro-deletion that are common and can be severe including 22q11.2 deletion syndrome, The Di George syndrome.
This is great news for mothers because it eliminates the risk of miscarriage of the pregnancy resulting from amniocentesis or chorionic villous sampling. It is important that an ultrasound scan is performed just before the blood test to confirm the pregnancy, and to check that the mother is not carrying twins or more. The Panorama test is not available in twin or donor pregnancies. The result of the Panorama is predictive to more than 99%.
For the last few years Obstetricians have been using the results of the Nuchal Translucency Scan to advise pregnant mothers on their risk of having a baby with a chromosomal abnormality such as Down syndrome, or other abnormalities (Edwards, Patau’s, Turners syndrome and Triploidy. The Nuchal Translucency Scan looks at the skin fold on the back of the baby’s neck at about 11-13weeks weeks+ 6days. This has been further refined by looking at the nasal bone of the baby with an additional blood test to identify few pregnancy hormones. This is the combined testie Admark in first trimester or Genmark in the second trimester and has achieved a predictive value of about 92% for Downs syndrome. Women with a high risk have an option to proceed to chorion villous sampling (CVS) or amniocentesis. These are invasive tests that carry a miscarriage risk of about 1:100. This is changing. The Panorama blood test has become available.

Panorama Test is offered for any mother who wants extra reassurance about the normality of the pregnancy. Women who may need it are those who are anxious about their baby having a chromosomal abnormality such as Downs, Edwards or Patau's syndrome, older women (particularly over 40 years) and those who have already had a chromosomally abnormal pregnancy often opt for the test. Those who are at particular risk of miscarriage should they have an amniocentesis or chorionic villous sample also find the test very attractive as it avoids an invasive procedure. It is helpful for those who have had a previous sex chromosome abnormality such as Turner’s syndrome. It may be performed for mothers at an increased risk following the combined test screening for Down’s syndrome, especially if they do not want amniocentesis or chorionic villous sample in the first instance.

How is the test done?

The mother has to read and sign a consent form and sign a form for data release.
An ultrasound scan is always done first.
Blood is taken from the mother vein of her arm(for a small extra fee)
This is a simple blood test from the vein in the woman's arm like any other blood test. There is no risk from having the blood test.
Two tubes need to be fully filled.
The tubes are immediately packaged and sent to the USA.

How long does it take to get a result?

The result is usually available within 9-12 working days. There is a one in thirty chance that no DNA is obtained. This is not a positive or negative test: it is an unsuccessful test. An offer of a repeat test is made free of charge. This is usually successful.

How is the result expressed?

The result is expressed as a probability. It is a screening test and not a diagnostic test. A result form of a normal test is shown below. A good test result gives a risk of a chromosomal problem of less than 1:10000. A bad result gives a risk of 1:2. A risk of 1:2 requires an amniocentesis or chorionic villous sampling depending on the clinical situation. The couple are counselled about this.

Panorama Example Report.pdf

How much Panorama costs?

The test is currently £500.99
This includes the price of the ultrasound scan and Blood test.

Blood test only from £399.99
Extended Panorama Blood test from £650.99 and includes all Microdeletions

What happens after Panorama?

Depending on how many weeks pregnant you are, you will still have the opportunity to have a 12 week scan privately or with the NHS. The focus of the 12 week scan will change as you will already have the result of the Downs syndrome test, so the 12 week scan will look at the baby in detail for structural abnormalities (these may exist without a chromosomal abnormality). You will still have the opportunity to have the later scans, such as the 20 weeks scan, as before. If the Panorama test is low risk then it is important that the person conducting the 12 week scan is aware of this. If the test is positive then you should return to The Brayford Studio or a good NHS unit for further counselling.

Panorama Test

The following microdeletion syndromes are screened:

22q11.2 Deletion Syndrome or Di George Syndrome : Babies born with this deletion syndrome often have heart defects, immune system problems, and mild to moderate intellectual disability. They may also have kidneys problems, feeding problems and or seizures.
1p36 Deletion Syndrome: Babies born with 1p36 deletion syndrome has a weak muscle tone, heart and other birth defects, intellectual disabilities, and behaviour problems. About half of them will have seizures.
Angelman Syndrome. Babies born with Angelman syndrome syndrome often have delayed milestones (like sitting, crawling and walking), seizures, and problems with balance and walking. The also have severe intellectual disability and most they do not develop speech.
Cri-du- chat Syndrome: Also known as5p minus. Babies born with Cri- du- chat syndrome typically have low birth weight, small head size, and decreased muscle tone. Feeding and breathing difficulties are also common. They have moderate – to – severe intellectual disabilities.
Prader- Willi Syndrome: Babies born with Prader- Willi Syndrome have low muscle tone and problems with feeding and gaining weight. They also have intellectual disability. As children and adults, they have rapid weight gain and often develop obesity-related medical problems.

The total frequency of these syndrome is 1 in 1000 live birth approximately.

Are there problems this test will not detect?

Yes. Structural abnormalities such as abnormal limbs, spina bifida, heart defects and a poorly growing baby will only be seen on scans and sometimes not until later stages on ultrasound scans. These scans should still be undertaken.
Panorama has been developed by

Natera Inc., San Carlos, California, USA www.panoramatest.com.

See the Video of Panorama for patients on our Facebook Page

Comparison between the 2 NIPT done at the Brayford Studio Lincolnshire, Lincoln

Harmony Test	Panorama Test
Available after 10 weeks	Available after 9 weeks

>99% T21 (Down’s Syndrome)	>99% T21 (Down’s Syndrome)
>98% T18 (Edwards Syndrome)	>99% T18 (Edwards Syndrome)
80% T13 (Patau’s Syndrome)	>99% T13 (Patau’s Syndrome)

Optional analysis of sex	Optional analysis of sex
chromosome (x,y) conditions	chromosome (x,y) conditions

Optional fetal gender determination	Optional fetal gender determination

Results in 9-12 business days	Results in 9-12 business days

Redraw rate of 5%	Redraw rate of 5-6%

<0.1% false positive rate	0% false positive rate

Fetal fraction %	Fetal fraction %

Also available in twin, multiples, singleton donor pregnancies	Not available for twin or donor and surrogate pregnancies

Microdeletions is not available	Microdeletions is available for an extra charge of £150.00

Harmony Website	Panorama Website